Present study elaborates on development and evaluation of floating–pulsatile drug delivery system intended for chronotherapy in hypertension. Novel floating–pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. To overcome limitations of various approaches for imparting buoyancy, we generated the system, which consisted of three different parts, a core tablet containing the active ingredient, an outer shell and a top cover buoyant layer. The coated tablet consists in a drug-containing core, coated by a hydrophilic polymer, which is responsible for a lag phase and their by of pulsatile release. The floating layer was optimized using different concentration of Methoce1 K100M and sodium bicarbonate, which provides buoyancy to increase the retention of the oral dosage form in the stomach. The effect of the different hydrophilic polymer with different viscosity grade and their combination in different ratios on the lag time and drug release was investigated. Developed formulations were evaluated for their buoyancy and dissolution. The results showed that the drug release after certain lag time was mainly due to the erosion of the dry coated layer. Floating time was controlled by the quantity and composition of the buoyant layer.
Loading....